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- Title
Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus.
- Authors
Dong-Hyun Kim; Byung-Keun Yang; Sang-Chul Jeong; Jun-Bo Park; Sung-Pill Cho; Das, Surajit; Jong-Won Yun; Song, Chi-Hyun
- Abstract
Mycelial growth and extracellular polysaccharide production of Phellinus linteus were optimal at pH 5 and 25 °C. Maximum biomass production (14.2 g l-1) was after 15 d of cultivation, whereas, extracellular polysaccharide was maximal (3.5 g l-1) after 21 d. The hypoglycemic effect of the polysaccharide, investigated in streptozotocin-induced diabetic rats, decreased plasma glucose, total cholesterol and triacylglycerol concentrations by 49%, 32%, and 28%, respectively, and aspartate aminotransferase activity by 20%. The results indicate the potential of this polysaccharide to prevent hyperglycemia in diabetic patients.
- Subjects
HYPOGLYCEMIA; INSULIN; POLYSACCHARIDES; BIOPOLYMERS; PHELLINUS; HYMENOCHAETACEAE
- Publication
Biotechnology Letters, 2001, Vol 23, Issue 7, p513
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/A:1010312513878