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- Title
Prevalence of Pathogenic Microbes within the Endometrium in Normal Weight vs. Obese Women with Infertility.
- Authors
King, Sarah; Osei, Florence; Marsh, Courtney
- Abstract
This study investigates the association between body mass index (BMI) and the composition of the endometrial microbiota in infertile women of childbearing age. This is a retrospective clinical study comparing the endometrial microbiota across body weight in 132 patients presenting for care at an infertility clinic. The reason for infertility was recurrent pregnancy loss (RPL) or implantation failure with a prior IVF cycle. Microbe analysis was completed by Igenomix Laboratory (Valencia, Spain) using two comprehensive panels. Patients were separated into three groups based on their results: normal, dysbiotic, and pathogenic. Prevalence of these groups was compared across BMI categories and statistical analysis was used to determine significance. Of the 132 endometrial samples collected, 80 (60.6%) were normal, 16 (12.1%) were dysbiotic, and 36 (27.3%) were pathogenic. Patients with a BMI ≥ 30 showed a statistically significant increase in pathogenic endometrium compared to normal weight controls (p = 0.029). Our conclusion is that the prevalence of pathogenic endometrium was significantly higher in the obese group compared with normal weight controls. There is a possible association between obesity and the endometrial microbiome.
- Subjects
UNITED States; CHILDBEARING age; ENDOMETRIAL diseases; BIOPSY; BODY mass index; ENDOMETRIUM; INFERTILITY; FISHER exact test; PSYCHOLOGY of women; HUMAN microbiota; RETROSPECTIVE studies; DESCRIPTIVE statistics; CHI-squared test; MANN Whitney U Test; DISEASE prevalence; HUMAN reproductive technology; MEDICAL records; ACQUISITION of data; LACTOBACILLUS; DATA analysis software; OBESITY; NONPARAMETRIC statistics
- Publication
Reproductive Medicine, 2024, Vol 5, Issue 2, p90
- ISSN
2673-3897
- Publication type
Article
- DOI
10.3390/reprodmed5020010