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- Title
The Discovery of Cyclic Lipopeptide Olenamidonins in a Deepsea-Derived Streptomyces Strain by Knocking Out a DtxR Family Regulator.
- Authors
Sun, Qiannan; Yu, Dongqi; Zhang, Xueqing; Xiao, Fei; Li, Wenli
- Abstract
Three new cyclic lipopeptides, olenamidonins A-C (1–3), in addition to two previously reported metabolites (4 and 5), were accumulated in the ΔdtxRso deletion mutant of deepsea-derived Streptomyces olivaceus SCSIO 1071. The structures of these cyclic lipopeptides were determined by a combination of spectroscopic methods and circular dichroism (CD) measurement. The antibacterial assay results showed that compounds 1–5 displayed different degrees of growth inhibition against multidrug-resistant (MDR) bacterial strains Enterococcus faecalis CCARM 5172 and Enterococcus faecium CCARM 5203 with minimum inhibitory concentrations (MICs) of 1.56−6.25 μg/mL.
- Subjects
STREPTOMYCES; ENTEROCOCCUS faecium; INHIBITION (Chemistry); ENTEROCOCCUS faecalis; CIRCULAR dichroism
- Publication
Marine Drugs, 2024, Vol 22, Issue 6, p262
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md22060262