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- Title
Beyond the mouth: Uncovering non-secretory multiple myeloma through oral symptoms.
- Authors
Chaves Isaias, Pedro Henrique; Gurgel Costa, Fábio Wildson; Gonçalves Holanda Amorim, Pedro Henrique; Domingues Alves da Silva, Raul Anderson; Bitu Sousa, Fabrício; Alves Pereira, Karuza Maria; Negreiros Nunes Alves, Ana Paula; Lima Mota, Mário Rogério
- Abstract
Non-secretory multiple myeloma (NSMM) is a rare cancer of plasma cells characterized by the absence of detectable monoclonal M protein in the blood or urine. A 57-year-old woman presented with mandibular pain but without intraoral swelling. Imaging studies revealed multiple osteolytic lesions in her mandible and pronounced root resorption of the left mandibular second molar. Biopsy results showed atypical plasmacytoid cells positive for anti-kappa, CD138, MUM1, and CD79a antibodies, but negative for anti-lambda and CD20. These results were indicative of a malignant plasma cell neoplasm. No abnormalities were revealed by free light chain assay or by serum or urine protein electrophoresis, leading to a diagnosis of NSMM. The patient began chemotherapy in conjunction with bisphosphonate therapy and achieved remission following treatment. This case underscores the critical role of dentists in the early detection and prevention of NSMM complications, as the disease can initially present in the oral cavity.
- Subjects
MULTIPLE myeloma; MONOCLONAL gammopathies; IMMUNOGLOBULIN light chains; PLASMA cells; BLOOD protein electrophoresis; ROOT resorption (Teeth)
- Publication
Imaging Science in Dentistry, 2024, Vol 54, Issue 2, p211
- ISSN
2233-7822
- Publication type
Case Study
- DOI
10.5624/isd.20230257