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- Title
Pneumatosis intestinalis in children with acute lymphoblastic leukemia and acute myeloid leukemia.
- Authors
Li, Siyang; Traubici, Jeffrey; Ethier, Marie-Chantal; Gillmeister, Biljana; Alexander, Sarah; Gassas, Adam; Sung, Lillian
- Abstract
Purpose: To describe symptoms, diagnostic features, treatments, and outcomes of pneumatosis intestinalis (PI) in pediatric patients being treated for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Methods: This retrospective chart review included 514 patients ≤18 years of age diagnosed with ALL or AML between January 1999 and December 2007. PI episodes were identified by radiology report reviews. Results: Twenty patients with ALL and four patients with AML presented 31 PI episodes. The median time between diagnoses of leukemia and PI was 1.0 month (interquartile range 0.8-6.4 months). Plain radiographs diagnosed all PI episodes. Computerized tomography (CT) and ultrasound were performed in 6 and 13 episodes, respectively. All CT and three ultrasounds demonstrated PI. Thirty episodes occurred exclusively in the colon, most commonly in the ascending ( n = 26) and transverse ( n = 18) segments. Treatment included complete bowel rest in 27 (87.1%) and intravenous broad-spectrum antibiotics in 29 (93.5%). One case required colectomy. Two episodes were untreated. There were no fatalities associated with PI. Conclusions: PI is uncommon in children with ALL or AML. Ultrasound is less sensitive than plain radiographs for diagnosis. PI occurred almost exclusively in the colon. With conservative management, most patients had excellent outcome.
- Subjects
LYMPHOBLASTIC leukemia; ANTI-infective agents; JUVENILE diseases; LYMPHOCYTIC leukemia; RADIOGRAPHY
- Publication
Supportive Care in Cancer, 2012, Vol 20, Issue 2, p343
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-011-1088-x