We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Slow-transit constipation with concurrent upper gastrointestinal dysmotility and its response to transcutaneous electrical stimulation.
- Authors
Yik, Yee; Clarke, Melanie; Catto-Smith, Anthony; Robertson, Val; Sutcliffe, Jonathan; Chase, Janet; Gibb, Susan; Cain, Timothy; Cook, David; Tudball, Coral; Hutson, John; Southwell, Bridget; Yik, Yee Ian; Clarke, Melanie C C; Catto-Smith, Anthony G; Robertson, Val J; Sutcliffe, Jonathan R; Chase, Janet W; Cain, Timothy M; Cook, David J
- Abstract
<bold>Purpose: </bold>Transcutaneous electrical stimulation (TES) speeds up colonic transit in children with slow-transit constipation (STC). This study examined if concurrent upper gastrointestinal dysmotility (UGD) affected response to TES.<bold>Methods: </bold>Radio-nuclear transit studies (NTS) were performed before and after TES treatment of STC as part of a larger randomised controlled trial. UGD was defined as delayed gastric emptying and/or slow small bowel transit. Improvement was defined as increase of ≥1 Geometric Centre (median radiotracer position at each time [small bowel = 1, toilet = 6]).<bold>Results: </bold>Forty-six subjects completed the trial, 34 had NTS after stimulation (21 M, 8-17 years, mean 11.3 years; symptoms >9 years). Active stimulation increased transit in >50% versus only 25% with sham (p = 0.04). Seventeen children also had UGD. In children with STC and either normal upper GI motility (NUGM) and UGD, NTS improved slightly after 1 month (57 vs. 60%; p = 0.9) and more after 2 months (88 vs. 40%; p = 0.07). However, mean transit rate significantly increased with NUGM, but not UGD (5.0 ± 0.2: 3.6 ± 0.6, p < 0.01).<bold>Conclusion: </bold>Transcutaneous electrical stimulation was beneficial for STC, with response weakly associated with UGD. As measured by NTS, STC children with NUGM responded slightly more, but with significantly greater increased transit compared to those with UGD. Higher numbers are needed to determine if the difference is important.
- Subjects
GASTROINTESTINAL motility disorders; CONSTIPATION; TRANSCUTANEOUS electrical nerve stimulation; GASTRIC emptying; RANDOMIZED controlled trials; SYMPTOMS; PEDIATRICS; THERAPEUTICS; COLON (Anatomy); COMPARATIVE studies; GASTROINTESTINAL motility; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RADIONUCLIDE imaging; RESEARCH; STATISTICAL sampling; PILOT projects; EVALUATION research; TREATMENT effectiveness
- Publication
Pediatric Surgery International, 2011, Vol 27, Issue 7, p705
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-011-2872-x