We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Macrophage migration inhibitory factor − 794 CATT5−8 microsatellite polymorphism and susceptibility of tuberculosis.
- Authors
Machado, Felipe Dominguez; Gehlen, Mirela; Caron, Vitória Schmidt; Mousquer, Gabriel Tassi; Bello, Graziele Lima; Anton, Camila; Bernardi, Rafaela Manzoni; Freitas, Alana Ambos; Unis, Gisela; Costa, Elis Regina Dalla; Rossetti, Maria Lucia Rosa; Silva, Denise Rossato
- Abstract
Purpose: The establishment of candidate genetic determinants associated with tuberculosis (TB) is a challenge, considering the divergent frequencies among populations. The objective of this study was to evaluate the association between MIF − 794 CATT 5−8 polymorphism and susceptibility to TB. Methods: Case–control study. Patients > 18 years, with pulmonary TB were included. The control group consisted of blood donors and household contacts, not relatives, healthy and > 18 years. MIF − 794 CATT 5−8 were genotyped using sequencing of PCR and capillary electrophoresis. Results: 126 patients and 119 controls were included. The genotype 5/5 was more frequent among cases (15.1%) than in controls (5.9%) (p = 0.019). Cases had more frequently the allele 5 (29.4%) as compared with controls (19.3%) (p = 0.010). Prevalence of 7/X + 8/X genotypes was not different between cases and controls (p = 0.821). There was no difference between patients with alleles 7 and 8 and those with alleles 5 and 6 (p = 0.608). Conclusions: The genotype 5/5 and the allele 5 of MIF − 794 CATT 5−8 were more frequent among TB patients than in controls.
- Subjects
BRAZIL; TUBERCULOSIS risk factors; HOSPITALS; GENETICS; SEQUENCE analysis; SINGLE nucleotide polymorphisms; MACROPHAGES; CASE-control method; ALLELES; LYMPHOKINES; CAPILLARY electrophoresis; COMPARATIVE studies; DISEASE susceptibility; ENZYMES; GENOTYPES; TUBERCULOSIS; DESCRIPTIVE statistics; POLYMERASE chain reaction
- Publication
Infection, 2021, Vol 49, Issue 3, p457
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-020-01562-w