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- Title
Detection of opsonic antibodies against Enterococcus faecalis cell wall carbohydrates in immune globulin preparations.
- Authors
Hufnagel, M.; Sixel, K.; Hammer, F.; Kropec, A.; Sava, I.; Theilacker, C.; Berner, R.; Huebner, J.
- Abstract
Three different commercially available polyvalent immune globulins (IG) were investigated for the existence of antibodies against cell wall carbohydrates of four different E. faecalis serotypes (using a cell wall carbohydrate-enzyme-linked immunosorbent assay), and whether these antibodies mediated opsonic killing (using an opsonic-killing assay). All three IG preparations contained antibodies against all four serotypes (CPS-A to CPS-D). However, only one of the three IG preparations showed opsonic killing against all four serotypes. Average killing was higher against serotypes A and B (72 and 79 %, respectively) than against serotypes C and D (30 and 37 %, respectively). Such IG preparations could play a role as an adjuvant therapeutic option in life-threatening infections with E. faecalis, particularly when resistant strains are involved.
- Subjects
IMMUNOHISTOCHEMISTRY; CARBOHYDRATES; CELL culture; CONFIDENCE intervals; ENZYME-linked immunosorbent assay; IMMUNOASSAY; IMMUNOGLOBULINS; T-test (Statistics); SEROTYPING; ENTEROCOCCUS faecium; DATA analysis software; DESCRIPTIVE statistics; IN vitro studies
- Publication
Infection, 2014, Vol 42, Issue 4, p749
- ISSN
0300-8126
- Publication type
Report
- DOI
10.1007/s15010-014-0628-y