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- Title
GEP-NET radiomics: a systematic review and radiomics quality score assessment.
- Authors
Staal, Femke C. R.; Aalbersberg, Else A.; van der Velden, Daphne; Wilthagen, Erica A.; Tesselaar, Margot E. T.; Beets-Tan, Regina G. H.; Maas, Monique
- Abstract
<bold>Objective: </bold>The number of radiomics studies in gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is rapidly increasing. This systematic review aims to provide an overview of the available evidence of radiomics for clinical outcome measures in GEP-NETs, to understand which applications hold the most promise and which areas lack evidence.<bold>Methods: </bold>PubMed, Embase, and Wiley/Cochrane Library databases were searched and a forward and backward reference check of the identified studies was executed. Inclusion criteria were (1) patients with GEP-NETs and (2) radiomics analysis on CT, MRI or PET. Two reviewers independently agreed on eligibility and assessed methodological quality with the radiomics quality score (RQS) and extracted outcome data.<bold>Results: </bold>In total, 1364 unique studies were identified and 45 were included for analysis. Most studies focused on GEP-NET grade and differential diagnosis of GEP-NETs from other neoplasms, while only a minority analysed treatment response or long-term outcomes. Several studies were able to predict tumour grade or to differentiate GEP-NETs from other lesions with a good performance (AUCs 0.74-0.96 and AUCs 0.80-0.99, respectively). Only one study developed a model to predict recurrence in pancreas NETs (AUC 0.77). The included studies reached a mean RQS of 18%.<bold>Conclusion: </bold>Although radiomics for GEP-NETs is still a relatively new area, some promising models have been developed. Future research should focus on developing robust models for clinically relevant aims such as prediction of response or long-term outcome in GEP-NET, since evidence for these aims is still scarce.<bold>Key Points: </bold>• The majority of radiomics studies in gastroenteropancreatic neuroendocrine tumours is of low quality. • Most evidence for radiomics is available for the identification of tumour grade or differentiation of gastroenteropancreatic neuroendocrine tumours from other neoplasms. • Radiomics for the prediction of response or long-term outcome in gastroenteropancreatic neuroendocrine tumours warrants further research.
- Subjects
PANCREATIC tumors; INTESTINAL tumors; STOMACH tumors; NEUROENDOCRINE tumors
- Publication
European Radiology, 2022, Vol 32, Issue 10, p7278
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-022-08996-w