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- Title
Derivation of a T2-weighted MRI total colonic inflammation score (TCIS) for assessment of patients with severe acute inflammatory colitis-a preliminary study.
- Authors
Hafeez R; Punwani S; Pendse D; Boulos P; Bloom S; Halligan S; Taylor SA; Hafeez, Rehana; Punwani, Shonit; Pendse, Doug; Boulos, Paul; Bloom, Stuart; Halligan, Steve; Taylor, Stuart A
- Abstract
<bold>Objective: </bold>To derive an MRI score for assessing severity, therapeutic response and prognosis in acute severe inflammatory colitis.<bold>Methods: </bold>Twenty-one patients with acute severe colitis underwent colonic MRI after admission and again (n = 16) after median 5 days of treatment. Using T2-weighted images, two radiologists in consensus graded segmental haustral loss, mesenteric and mural oedema, mural thickness, and small bowel and colonic dilatation producing a total colonic inflammatory score (TCIS, range 6-95). Pre- and post-treatment TCIS were compared, and correlated with CRP, stool frequency, and number of inpatient days (therapeutic response marker). Questionnaire assessment of patient worry, satisfaction and discomfort graded 1 (bad) to 7 (good) was administered<bold>Results: </bold>Admission TCIS correlated significantly with CRP (Kendall's tau=0.45, 95% confidence interval [CI] 0.11-0.79, p = 0.006), and stool frequency (Kendall's tau 0.39, 95% CI 0.14-0.64, p = 0.02). TCIS fell after treatment (median [22 range 15-31]) to median 20 [range 8-25], p = 0.01. Admission TCIS but not CRP or stool frequency was correlated with length of inpatient stay (Kendall's tau 0.40, 95% CI 0.11-0.69, p = 0.02). Patients reported some discomfort (median score 4) during MRI.<bold>Conclusions: </bold>MRI TCIS falls after therapy, correlates with existing markers of disease severity, and in comparison may better predict therapeutic response.
- Publication
European Radiology, 2011, Vol 21, Issue 2, p366
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-010-1934-0