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- Title
The Potent Heme Oxygenase Inducing Action of Arsenic and Parasiticidal Arsenicals.
- Authors
Sardana, Mohinder K.; Drummond, George S.; Sassa, Shigeru; Kappas, Attallah
- Abstract
The administration of trivalent arsenic, either as sodium arsenite or as the trypanocidal drug melarsoprol, to rats produced a profound induction of microsomal heme oxygenase (EC 1.14.99.3) in both liver and kidney and a concomitani decrease in cytochrome P-450 content. In addition, perturbations of δ-aminolevulinate synthase were observed which showed an initial decline followed by a rebound increase in the activity of this enzyme with arsenical treatment. Pentavalent arsenic did not induce hepatic heme oxygenase but did induce the enzyme in kidney, although to a lesser extent (50%) than trivalent arsenic. Treatment of isolated chick embryo liver cells in vitro with sodium arsenite or the parasiticidal drug melarsoprol also showed a potent induction of heme oxygenase. These findings describe a new and potent ability of arsenic and parasiticidal arsenicals to induce heme oxygenase resulting in enhanced degradation of cellular heme. Copyright © 1981 S. Karger AG, Basel
- Publication
Pharmacology, 1981, Vol 23, Issue 5, p247
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000137557