We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Acetylcholine-Releasing Effect of Primycin, a Highly Active Antibiotic.
- Authors
Ádám-Vizi, Vera; Horváth, I.; Vizi, E.S.
- Abstract
The effect of primycin, an antibiotic known to inhibit potassium conductance, was studied on acetylcholine (ACh) release from the nerve terminals of the Auerbach plexus and cortical slice of the rat. Primycin enhanced the resting release of ACh; however, it failed to affect the amount of ACh released by a single shock. It has no effect on Na+K+-activated ATPase. Its effect on ACh release was prevented by tetrodotoxin and by Ca removal. It is concluded that its effect on potassium conductance might account for its ACh-releasing effect: it produces depolarization and spontaneous firing. Copyright © 1980 S. Karger AG, Basel
- Publication
Pharmacology, 1980, Vol 20, Issue 5, p268
- ISSN
0031-7012
- Publication type
Article
- DOI
10.1159/000137372