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- Title
Specificities of Ischemic Stroke Risk Factors in Arab-Speaking Countries.
- Authors
abboud, Halim; Sissani, Leila; Labreuche, Julien; arauz, antonio; Bousser, Marie-Germaine; Bryer, alain; Chamorro, angel; Fisher, Marc; Ford, Ian; Fox, Kim M.; Hennerici, Michael G.; Lavados, Pablo M.; Massaro, ayrton; Mattle, Heinrich P.; Munoz Collazos, Mario; Rothwell, Peter M.; Steg, Philippe Gabriel; Vicaut, Eric; Yamouth, Bassem; amarenco, Pierre
- Abstract
Background: Stroke is largely preventable, and therefore, a better understanding of risk factors is an essential step in reducing the population stroke rate and resulting disease burden in Arab countries. Summary: We performed 2 separate analyses in 2 similar populations of patients with noncardioembolic ischemic stroke. This first involved 3,635 patients in the Outcomes in Patients with TIA and Cerebrovascular disease (OPTIC) registry (followed for 2 years), with baseline collection of the usual risk factors and 5 socioeconomic variables (unemployment status, residence in rural area, living in fully serviced accommodation, no health-insurance coverage, and low educational level). The second involved patients in the PERFORM trial ( n = 19,100 followed up for 2 years), with baseline collection of the usual risk factors and 1 socioeconomic variable (low educational level). The primary outcome was a composite of nonfatal stroke, nonfatal myocardial infarction, or cardiovascular death. Stroke risk factors were more prevalent in patients in Arab countries. The incidence of major cardiovascular events (MACE; age- and gender-adjusted) was higher in Arab countries (OPTIC, 18.5 vs. 13.3%; PERFORM, 18.4 vs. 9.7%; both p ≤ 0.0001). These results remained significant after adjustment on risk factors and were attenuated in OPTIC after further adjustment on socioeconomic variables (hazard ratio 1.24; 95% CI 0.98-1.55; p = 0.07). Key Messages: Patients with ischemic stroke living in Arab countries had a lower mean socioeconomic status, a much higher prevalence of diabetes mellitus, and a higher rate of MACE compared with patients from non-Arab countries. This finding is partly explained by a higher prevalence of risk factors and also by a high prevalence of poverty and low educational level.
- Subjects
CORONARY heart disease risk factors; CARDIOVASCULAR diseases risk factors; DIABETES risk factors
- Publication
Cerebrovascular Diseases, 2017, Vol 43, Issue 3/4, p169
- ISSN
1015-9770
- Publication type
Article
- DOI
10.1159/000454776