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- Title
L‐type calcium current of isolated rat cardiac myocytes in experimental uraemia.
- Authors
Donohoe, Paul; McMahon, Aisling C.; Walgama, Omal V.; Bertaso, Federica; Dockrell, Mark E. C.; Cramp, Hilary A.; Mullen, Adrian M.; Shattock, Michael J.; Hendry, Bruce M.; James, Andrew F.
- Abstract
Background. End‐stage renal failure is associated with a low‐output cardiomyopathy, left ventricular hypertrophy and increased QTc dispersion. Cardiac dysfunction is prevalent in patients at the beginning of dialysis and is an important predictor of mortality. Ca2+ influx through voltage‐gated L‐type Ca2+ channels plays a key role in the excitation–contraction coupling of cardiac myocytes. The purpose of this study was to examine the effect of subtotal nephrectomy (SNx) in the rat on both cardiac L‐type Ca2+ currents and action potential duration.
- Publication
Nephrology Dialysis Transplantation, 2000, Vol 15, Issue 6, p791
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/15.6.791