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- Title
Microneedle assisted delivery of epidermal and dermal stem cells to promote hair growth.
- Authors
Xiao, Tong; He, Gaiying; Geng, Hongya; Wang, Yi; Sun, Shuqing
- Abstract
Advances in effective treatment options for hair loss hold paramount importance for individuals on both psychological and physical levels. Cell-based therapies for hair loss hold great promise due to their potential capability to regenerate hair follicles, providing a permanent solution to hair loss. However, a unique set of challenges is presented to ensure delivery efficacy and survival of cells. As a minimally invasive technology, microneedles can bypass the skin to deliver therapeutic agents directly to the target site. Herein, a facile approach has been developed for the transdermal delivery of epidermal and dermal stem cells using microneedle arrays. Specifically, dissolvable PVP microneedles supplemented with cell culture medium were fabricated and used to enhance the transdermal delivery of epidermal and dermal stem cells isolated from newborn mice. The results indicate that these soluble microneedles can effectively enhance the transdermal delivery of epidermal and dermal stem cells, subsequently leading to successful hair regeneration in C57BL/6 mice. This method avoided the use of ice-microneedles for the transdermal delivery of cells and provides a common and facile route for transdermal delivery of cells and may find wide applications in stem-cell based therapy.
- Subjects
STEM cells; HAIR cells; HAIR growth; HAIR follicles; BALDNESS; LABORATORY mice; CELL culture; SKIN regeneration
- Publication
Journal of Materials Science, 2024, Vol 59, Issue 19, p8427
- ISSN
0022-2461
- Publication type
Article
- DOI
10.1007/s10853-024-09592-7