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- Title
Cefodizime and cefotaxime in acute exacerbations of chronic bronchitis: a randomized double-blind prospective study in 180 patients.
- Authors
Maesen, F. P. V.; Davies, B. I.; van den Bergh, J. J. A. M.; Gubbelmans, H. L. L.; Meek, J. C. E.; Geraedts, W. H.; Maesen, F P; van den Bergh, J J; Gubbelmans, H L; Meek, J C
- Abstract
In a double-blind prospective study, 180 patients admitted to hospital with acute purulent exacerbations of chronic bronchitis were treated for seven days with twice daily 1 g intramuscular injections of either cefodizime or cefotaxime. Sputum cultures performed before, during and immediately after treatment showed complete eradication of the infection in 89/90 given cefodizime and 86/90 receiving cefotaxime. Some symptomatic Pseudomonas aeruginosa superinfections occurred with each agent. During the follow-up week, recurrences or reinfections after apparent clearance occurred in 15 patients given cefodizime and in 21 receiving cefotaxime. Pharmacokinetic studies in blood showed mean Cmax values of 50.8 mg/l for cefodizime and 36.5 mg/l for cefotaxime, corresponding values in the sputum being 1.61 and 0.62 mg/l. Mean AUC values in both blood and sputum were 2 1/2- to 3-fold higher for cefodizime. Some features suggested better performance by cefodizime than by cefotaxime, but the clinical results were not statistically significantly different.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1990, Vol 25, Issue 3, p413
- ISSN
0305-7453
- Publication type
journal article