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- Title
In-vitro microbiological activities of DuP 105 and DuP 721, novel synthetic oxazolidinones.
- Authors
Brumfitt, W.; Hamilton-Miller, J. M. T.; Hamilton-Miller, J M
- Abstract
DuP 105 and 721, synthetic antibiotics belonging to a totally novel chemical class (oxazolidinones), have been found to be active in vitro against a wide range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. DuP 721 had geometric mean MICs ranging from 1.1 to 16 mg/l against 167 strains of Staph. aureus, Staph. epidermidis, Staph. saprophyticus, streptococci of Groups A, B and D and diphtheroids. DuP 105 was between 1.5 and eight-fold less active. Bacteroides fragilis strains were also susceptible to the DuP compounds (mean MICs being 8.3 and 14.9 mg/l for DuP 721 and 105, respectively), but other Gram-negative species and yeasts were not inhibited by concentrations in excess of 100 mg/l. Both compounds had a predominantly bacteriostatic action. No primary resistance was found, and the incidence of resistant variants in 105 strains tested was less than 1 per 10(8) bacteria.
- Subjects
ANTI-infective agents; ANTIBIOTICS; BACTERIA; CANDIDA albicans; DRUG resistance in microorganisms; ENTEROBACTERIACEAE; GRAM-positive bacteria; HETEROCYCLIC compounds; MICROBIAL sensitivity tests; PSEUDOMONAS; STAPHYLOCOCCUS; TIME; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1988, Vol 21, Issue 6, p711
- ISSN
0305-7453
- Publication type
journal article