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- Title
Penicillin susceptibility testing of gonococci by disc diffusion.
- Authors
Jacobs, Michael R.; Tomashefski, Joseph F.; Franco, Amalia; Anton, Peter A.; Jacobs, M R; Tomashefski, J F Jr; Franco, A; Anton, P A
- Abstract
This study investigated the use of various beta-lactam discs in the detection of penicillin sensitive, intermediate resistant and resistant strains (minimal inhibitory concentrations of penicillin G of less than 0.06, 0.06 to 0.25, and greater than 0.25 mg/l respectively). Discs containing 0.15 and 0.6 microgram of penicillin G, and 5 microgram of methicillin were the most useful in separating the three groups. Cut-off zones between sensitive, intermediate resistant and resistant strains are 12 and 24 mm for 0.15 microgram penicillin discs; 24 and 32 mm for 0.6 microgram penicillin discs; and 20 and 30 mm for 5 microgram methicillin discs. Oxacillin discs (1 microgram) were useful in separating resistant from both sensitive and intermediate resistant strains at a cut-off zone of 8 mm. Use of a combination of discs provides the best index of susceptibility group, and at least two should be used
- Subjects
DOSE-effect relationship in pharmacology; HYDROLASES; MICROBIAL sensitivity tests; NEISSERIA; PENICILLIN G; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1981, Vol 7, Issue 4, p319
- ISSN
0305-7453
- Publication type
journal article