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- Title
Identification of metabolic correlates of mild cognitive impairment in Parkinson's disease using magnetic resonance spectroscopic imaging and machine learning.
- Authors
Cengiz, Sevim; Arslan, Dilek Betul; Kicik, Ani; Erdogdu, Emel; Yildirim, Muhammed; Hatay, Gokce Hale; Tufekcioglu, Zeynep; Uluğ, Aziz Müfit; Bilgic, Basar; Hanagasi, Hasmet; Demiralp, Tamer; Gurvit, Hakan; Ozturk-Isik, Esin
- Abstract
Objective: To investigate metabolic changes of mild cognitive impairment in Parkinson's disease (PD-MCI) using proton magnetic resonance spectroscopic imaging (1H-MRSI). Methods: Sixteen healthy controls (HC), 26 cognitively normal Parkinson's disease (PD-CN) patients, and 34 PD-MCI patients were scanned in this prospective study. Neuropsychological tests were performed, and three-dimensional 1H-MRSI was obtained at 3 T. Metabolic parameters and neuropsychological test scores were compared between PD-MCI, PD-CN, and HC. The correlations between neuropsychological test scores and metabolic intensities were also assessed. Supervised machine learning algorithms were applied to classify HC, PD-CN, and PD-MCI groups based on metabolite levels. Results: PD-MCI had a lower corrected total N-acetylaspartate over total creatine ratio (tNAA/tCr) in the right precentral gyrus, corresponding to the sensorimotor network (p = 0.01), and a lower tNAA over myoinositol ratio (tNAA/mI) at a part of the default mode network, corresponding to the retrosplenial cortex (p = 0.04) than PD-CN. The HC and PD-MCI patients were classified with an accuracy of 86.4% (sensitivity = 72.7% and specificity = 81.8%) using bagged trees. Conclusion: 1H-MRSI revealed metabolic changes in the default mode, ventral attention/salience, and sensorimotor networks of PD-MCI patients, which could be summarized mainly as 'posterior cortical metabolic changes' related with cognitive dysfunction.
- Subjects
PARKINSON'S disease; MILD cognitive impairment; MAGNETIC resonance imaging; SUPERVISED learning; DEFAULT mode network; MACHINE learning
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2022, Vol 35, Issue 6, p997
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-022-01030-6