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- Title
Novel HPPD inhibitors: triketone 2H-benzo[b][1,4]oxazin-3(4H)-one analogs.
- Authors
Hua-Bin Li; Lei Li; Jun-Xian Li; Ting-Feng Han; Jing-Li He; You-Quan Zhu
- Abstract
BACKGROUND: Herbicides that inhibit 4-hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) are very important for grass weed control. In order to discover novel HPPD herbicides, a series of triketone 2H-benzo[b] oxazin-3(4H)-one analogs was designed and synthesized. RESULTS: In comparison with the commercial triketone HPPD herbicide mesotrione (IC50 =0.252 μM), some of these new triketone analogs displayed excellent HPPD inhibitory potency in vitro, for example B39 (IC50 =0.172 μM) and B41 (IC50 =0.156 μM). In addition, some of these compounds exhibited pre- and post-emergence herbicidal activity similar to mesotrione when applied at 375 g/ha. CONCLUSION: Many of the title compounds described in this paper could be important lead structures for the further development of novel HPPD herbicides.
- Subjects
HERBICIDES; CHEMICAL inhibitors; BIOSYNTHESIS; MESOTRIONE; PLANT species
- Publication
Pest Management Science, 2018, Vol 74, Issue 3, p579
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.4739