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- Title
Toxicology of insecticides to mammals.
- Authors
Marrs, Timothy C
- Abstract
Many insecticides target structures or functions in non-target species, including mammals. This is particularly true of those that target the insect nervous system, such as the organochlorines, anticholinesterases and GABA antagonists. Another group of insecticides target structures or functions not present in mammals, and this group of insecticides has considerable target species specificity, but there are often potential targets in mammals. Octopamine is closely related to adrenaline and amitraz (an octopamine receptor agonist) and acts in mammals at α2-adrenergic receptors. Although there are potential targets in mammals for juvenile hormone mimics and ecdysone receptor agonists, there is no evidence that the mammalian toxicity of either group is related to their insecticidal activity. Nor do chitin synthesis inhibitors have high mammalian toxicity. Copyright © 2012 Society of Chemical Industry
- Subjects
TOXICOLOGY of insecticides; MAMMAL physiology; NERVOUS system; ORGANOCHLORINE compounds; CHOLINESTERASE inhibitors; OCTOPAMINE; ECDYSONE
- Publication
Pest Management Science, 2012, Vol 68, Issue 10, p1332
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.3362