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- Title
Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2.
- Authors
Mikiko Soejima; Yoshiro Koda
- Abstract
Abstract??The two genesSLC24A5andSLC45A2were recently identified as major determinants of pigmentation in humans and in other vertebrates. The allele p.A111T in the former gene and the allele p.L374F in the latter gene are both nearly fixed in light-skinned Europeans, and can therefore be considered ancestry informative marker (AIMs). AIMs are becoming useful for forensic identification of the phenotype from a DNA profile sampled, for example, from a crime scene. Here, we generate new allelic data for these two genes from samples of Chinese, Uygurs, Ghanaians, South African Xhosa, South African Europeans, and Sri Lankans (Tamils and Sinhalese). Our data confirm the earlier results and furthermore demonstrate that theSLC45A2allele is a more specific AIM than theSLC24A5allele because the former clearly distinguishes the Sri Lankans from the Europeans.
- Subjects
HUMAN skin color genetics; GENETIC polymorphisms; SLC24A5 gene; SLC45A2 gene; POPULATION genetics
- Publication
International Journal of Legal Medicine, 2007, Vol 121, Issue 1, p36
- ISSN
0937-9827
- Publication type
Article