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- Title
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.
- Authors
Hotchkiss, Richard S.; Monneret, Guillaume; Payen, Didier
- Abstract
Sepsis - which is a severe life-threatening infection with organ dysfunction - initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.
- Subjects
IMMUNOSUPPRESSION; SEPTICEMIA treatment; IMMUNOTHERAPY; HOST-parasite relationships; BIOMARKERS; DRUG administration
- Publication
Nature Reviews Immunology, 2013, Vol 13, Issue 12, p862
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3552