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- Title
Activation and regulation of the inflammasomes.
- Authors
Latz, Eicke; Xiao, T. Sam; Stutz, Andrea
- Abstract
Inflammasomes are key signalling platforms that detect pathogenic microorganisms and sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. In this Review, we discuss the complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response, and we highlight the similarities to another molecular signalling platform - the apoptosome - that monitors cellular health. Extracellular regulatory mechanisms are discussed, as well as the intracellular control of inflammasome assembly, for example, via ion fluxes, free radicals and autophagy.
- Subjects
CYTOKINES; INTERLEUKIN-1; AUTOPHAGY; CELLULAR immunity; MICROORGANISMS; MONOKINES; FREE radical reactions
- Publication
Nature Reviews Immunology, 2013, Vol 13, Issue 6, p397
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3452