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- Title
Do T cells need endogenous peptides for activation?
- Authors
Gascoigne, Nicholas R. J.
- Abstract
T cells are sensitive to small numbers of antigenic peptide-MHC ligands that are distributed among an excess of endogenous peptide-MHC complexes on the surface of antigen-presenting cells. Although there are accumulating data that indicate a role for these endogenous peptide-MHC complexes in T-cell receptor triggering, whether they are necessary, and the nature of their function, is controversial. In this Opinion article, I argue that endogenous peptide-MHC complexes are required for T-cell stimulation and that their mechanism of action differs between CD4(+) and CD8(+) T cells.
- Subjects
IMMUNOLOGY; T cells; LYMPHOCYTES; PEPTIDES; EPITOPES; ANTIGENS
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 11, p895
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri2431