We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Impact of MHC class I diversity on immune control of immunodeficiency virus replication.
- Authors
Goulder, Philip J. R.; Watkins, David I.
- Abstract
The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.
- Subjects
MAJOR histocompatibility complex; T-cell receptor genes; VIRAL replication; AIDS vaccines; IMMUNOGENETICS; HIV prevention; HISTOCOMPATIBILITY antigens; HIV; HIV infections; PRIMATES; RESEARCH funding; T cells; VIRAL vaccines; RNA virus infections; PREVENTION; PHYSIOLOGY
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 8, p619
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2357