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- Title
THE FUNCTION OF E- AND ID PROTEINS IN LYMPHOCYTE DEVELOPMENT.
- Authors
Engel, Isaac; Murre, Cornelis
- Abstract
Helix?loop?helix proteins are essential factors for lymphocyte development and function. In particular, E-proteins are crucial for commitment of lymphoid progenitors to the B- and T-cell lineages. E-proteins are negatively regulated by the Id class of helix?loop?helix proteins. The Id proteins function as dominant-negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here, we review the role of E-proteins and their Id protein antagonists in lymphocyte proliferation and developmental progression. In addition, we discuss how E-protein activity and Id gene expression are regulated by T-cell receptor (TCR) and pre-TCR-mediated signalling.
- Subjects
HELIX-loop-helix motifs; PROTEINS; LYMPHOCYTES; T cell receptors
- Publication
Nature Reviews Immunology, 2001, Vol 1, Issue 3, p193
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/35105060