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- Title
Functions of RNAi Pathways in Ribosomal RNA Regulation.
- Authors
Shatskikh, Aleksei S.; Fefelova, Elena A.; Klenov, Mikhail S.
- Abstract
Argonaute proteins, guided by small RNAs, play crucial roles in gene regulation and genome protection through RNA interference (RNAi)-related mechanisms. Ribosomal RNAs (rRNAs), encoded by repeated rDNA units, constitute the core of the ribosome being the most abundant cellular transcripts. rDNA clusters also serve as sources of small RNAs, which are loaded into Argonaute proteins and are able to regulate rDNA itself or affect other gene targets. In this review, we consider the impact of small RNA pathways, specifically siRNAs and piRNAs, on rRNA gene regulation. Data from diverse eukaryotic organisms suggest the potential involvement of small RNAs in various molecular processes related to the rDNA transcription and rRNA fate. Endogenous siRNAs are integral to the chromatin-based silencing of rDNA loci in plants and have been shown to repress rDNA transcription in animals. Small RNAs also play a role in maintaining the integrity of rDNA clusters and may function in the cellular response to rDNA damage. Studies on the impact of RNAi and small RNAs on rRNA provide vast opportunities for future exploration.
- Subjects
RNA regulation; RIBOSOMAL RNA; SMALL interfering RNA; RNA interference; NON-coding RNA; RIBOSOMAL proteins
- Publication
Non-Coding RNA, 2024, Vol 10, Issue 2, p19
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna10020019