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- Title
硬毛粗盖孔菌子实体提取物对小鼠免疫功能及抗氧化能力的影响.
- Authors
王洪发; 刘颖; 王玉悦; 包海鹰
- Abstract
In this study, fruiting bodies of Funalia trogii were extracted in order by petroleum ether, ethyl acetate, and water, and then the resultant extract derived from each solvent was used to administer immunosuppressive mice induced by cyclophosphamide (CTX, 80 mg·kg-1) at high, medium, and low doses, respectively. Mice in each treatment group were measured for organ indices, observed for organ sections by hematoxylin-eosin (HE) and immunohistochemical staining, and determined for serum cytokines, malondialdehyde (MDA), superoxide dismutase (SOD), lysozyme and serum hemolysin level.The results showed that mice administered with high dose water extract had highly significant (P<0.01) greater thymus index and liver index, and significant greater spleen index compared with mice in the CTX group. Mice administered with high dose ethyl acetate extract showed highly significant (P<0.01) greater spleen index and live index than mice in the CTX group. Excretion of IL2 and IL-4 were significantly (P<0.01) increased in mice administered with high dose water extract compared with CTX treated mice. Compared with CTX treated mice, high dose water extract treated mice also had greater SOD levels. In contrast, their MDA levels were significantly lower than CTX treated mice and levamisole hydrochloride treated mice. Total antioxidant capacity was highly significantly (P<0.01) greater in high dose water extract treated mice and high dose ethyl acetate treated mice than in CTX treated mice.Water extract treated mice had a larger population of thymus and spleen cells than CTX treated mice. In summation, the results suggest that Funalia trogii can enhance immune function and antioxidant activity in vivo, thereby providing a basis for further development and utilization of it.
- Subjects
OXIDANT status; ETHYL acetate; SUPEROXIDE dismutase; IMMUNOSTAINING; THYMUS
- Publication
Acta Edulis Fungi, 2020, Vol 27, Issue 2, p51
- ISSN
1005-9873
- Publication type
Article
- DOI
10.16488/j.cnki.1005-9873.2020.02.008