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- Title
The problem of uncertain adherence to study interventions: what can we conclude?
- Authors
Haslinger, C
- Abstract
Intrahepatic cholestasis of pregnancy (ICP), the most common liver disease in pregnancy, is characterised by elevated bile acid concentrations and maternal pruritus, and has been associated with increased rates of stillbirth, preterm birth and neonatal unit admission. The results are congruent with those of the original study: there was no beneficial effect of treatment with UDCA on bile acid concentration or itch score. Fetal complications have been associated with rising serum bile acids (Glantz et al. I Hepatology i 2004;40:467-74) and, according to a recent individual patient data meta-analysis (Ovadia et al. I Lancet i 2019;393:899-909), the risk of stillbirth increased in women with serum bile acid concentrations of 100 mol/l or higher.
- Subjects
MEDICAL personnel; PATIENT compliance; BILE acids; URSODEOXYCHOLIC acid; CHOLESTASIS; UNCERTAINTY; PREGNANCY complications
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2021, Vol 128, Issue 6, p1076
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/1471-0528.16613