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- Title
Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.
- Authors
Belotserkovskaya, Ekaterina; Golotin, Vasily; Uyanik, Burhan; Demidov, Oleg N.
- Abstract
Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease's development in old age.
- Subjects
HEMATOPOIESIS; HEMATOPOIETIC system; OLDER people; CELL populations; GENETIC mutation; OLD age; IMMUNOSENESCENCE
- Publication
Cell Death Discovery, 2023, Vol 9, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-023-01590-z