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- Title
The ameliorative effect of acetylsalicylic acid plus ascorbic acid against renal injury in corn syrup-fed rats.
- Authors
Yesilot, Sukriye; Asci, Halil; Ozgocmen, Meltem; Saygin, Mustafa; Armagan, Ilkay; Cicek, Ekrem
- Abstract
Dietary consumption of commercially prepared (often through processing) corn syrup can activate reactive oxygen species and the inflammatory pathways observed in kidney damage in humans and experimental animals. The study sought to assess the effects of the antioxidant properties of acetylsalicylic (ASA) and ascorbic acid (AA) on corn syrup (CS)-induced kidney damage. The rats (male Sprague-Dawley) were classified into 5 groups as follows: control (C), CS, CS+ASA (ASA-10 mg/kg/day/po), CS+AA (AA-200 mg/kg/day/po) and CS+ASA+AA (combination therapy with ASA and AA doses). Biochemical, histopathological and immunohistochemical analyzes were performed on blood and tissue samples. The levels of malondialdehyde (MDA) were rised in the CS-fed rats compared to control (p<0.001) and were reduced in the ASA, AA and ASA+AA treated groups (p=0.001 for all) compared to the CS group. The catalase (CAT) activities were reduced in the CS-fed group (p=0.001) compared to the control (p<0.001) and significantly rised in ASA+AA-treated group (p<0.001) compared to the CS-fed group. Significant histopathological changes including tubular vacuoler degeneration, tubular dilatation, cortical and medullar haemorrhage, mononuclear cell infiltration, and increased inducible nitric oxide synthase (iNOS) and tumor necrosis factor-a (TNF-a) staining were observed in the CS group. Combination theraphy reversed all these changes. The administration of ASA and AA for the treatment of kidney damage due to corn syrup consumption provides an ideal target for improving oxidative stress and potential therapeutic treatments.
- Subjects
ASPIRIN; CORN syrup; KIDNEY injuries; VITAMIN C; IMMUNOHISTOCHEMISTRY; NITRIC-oxide synthases
- Publication
Veterinary Journal of Mehmet Akif Ersoy University, 2022, Vol 7, Issue 1, p26
- ISSN
2148-6239
- Publication type
Article
- DOI
10.24880/maeuvfd.981913