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- Title
Survival, Failure Patterns, and Toxicity Outcomes in Endometrial Cancer Patients Receiving Adjuvant Radiotherapy.
- Authors
Halis, Hatice; Açıkgöz, Sedef Gökhan
- Abstract
Introduction This study aimed to investigate the survival outcomes, recurrence patterns, and treatment-related toxicities of endometrial cancer (EC) patients who underwent adjuvant radiotherapy. Materials and Methods Between January 2012 and December 2021, one hundred fourteen patients who underwent adjuvant radiotherapy with the diagnosis of endometrial cancer were retrospectively analyzed. Cases were evaluated for overall survival (OS), disease-free survival (DFS), local recurrence-free survival (LRFS), cancer-specific survival (CSS), and distant metastasis-free survival (DMFS). Results Median follow-up was 63 months (8 -135). At 5 years OS, DFS, LRFS, CSS, and DMFS were 85.5%, 90.5%, 98.9%, 94.1%, and 90.5%, respectively. Univariate analysis of lymphovascular space invasion (LVSI) is statistically significant for DFS, DMFS, and CSS, respectively (p=0.019, p=0.019, p=0.021) and histology, tumor grade, stage were statistically significant for LRFS, respectively (p=0.031, p=0.010, p=0.049). Grade 1 and 2 acute gastrointestinal toxicity were observed in 40 patients (35.1%). Grade 1 acute genitourinary toxicity was observed in 35 patients (30.7%). Grade 3 late genitourinary and gastrointestinal toxicity was observed in 0.9% and 1.8%, respectively Conclusion Histology, grade, LVSI, and stage didn't significantly affect overall survival, but LVSI and stage were the most influential prognostic factors on relapse patterns. Adjuvant radiotherapy is safe and well tolerated by patients wiThendometrial cancer with acceptable toxicity.
- Subjects
TREATMENT of endometrial cancer; CANCER radiotherapy complications; CANCER relapse; CANCER prognosis; MEDICAL statistics
- Publication
Sakarya Tıp Dergisi, 2023, Vol 13, Issue 3, p465
- ISSN
2146-2585
- Publication type
Article
- DOI
10.31832/smj.1309164