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- Title
腔隙性脑梗死伴脑白质病变患者血清miR-146a 和NSE 水平 与MoCA 评分的关系研究*.
- Authors
李艳华; 张丽冉; 夏瑞雪; 戴建宁; 夏瑞霖; 王金丽
- Abstract
To study the relationship between serum miR-146a and neuron-specific ene purification enzyme (NSE) levels and Montreal cognitive assessment scale (MoCA) scores in patients with lacunar cerebral infarction (LI) with leuboencephalopathy (WML). 108 patients with LI and WML who were admitted to our hospital from March 2017 to March 2019 were included in the study, and were recorded as the LI with WML group. In addition, 100 cases of WML patients and 100 cases of LI patients who were admitted at the same time were recorded as WML group and LI group, and 100 cases of healthy people who underwent physical examination in our hospital at the same time were taken as the control group. Serum miR-146a and NSE levels and MoCA scores of the four groups were compared, and the correlation was analyzed. The relative expression of serum miR-146a in the LI with WML group, WML group and LI group were lower than that in the control group, while the relative expression of serum miR-146a in the LI with WML group were significantly lower than that in the WML group and LI group (all P<0.05). The serum NSE level of the LI with WML group, WML group and LI group were significantly higher than that in the control group, and the serum NSE level of the LI with WML group were significantly higher than that in the WML group and LI group (all P<0.05). The total MoCA score of the LI with WML group were significantly lower than that in the WML group and LI group, and the total MoCA score of the WML group and the LI group were significantly lower than that in the control group (all P<0.05). Pearson correlation analysis showed that the relative expression of serum miR-146a in the LI with WML group was positively correlated with the total MoCA score (P<0.05), while the serum NSE level was negatively correlated with the total MoCA score (P<0.05). Serum miR-146a level in LI with WML patients is significantly lower, while the serum NSE level is significantly higher, and they are correlated with MoCA score, which may play a crucial role in the occurrence and development of cognitive impairment.
- Subjects
MONTREAL Cognitive Assessment; CEREBRAL infarction; COGNITION disorders; STATISTICAL correlation; CONTROL groups
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 21, p4139
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.21.031