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- Title
Beclin1 与p53 在唾液腺多形性腺瘤和癌在唾液腺多形性腺瘤中的表达 及与临床病理因素的关系研究
- Authors
曹星华; 胡温庭; 孙学辉; 范欣; 董超; 栾可峰
- Abstract
Objective: To analyze the expressions of autophagic related genes Belin1 and p53 in pleomorphic adenoma(PA), carcinoma in pleomorphic adenoma(CPA) and its relationship with clinicopathological factors. Methods: 45 cases of PA excised in our hospital from January 2013 to August 2017 were selected as PA group, 32 cases of CPA specimens as CPA group, 30 normal parotid tissue as control group, the expression of Belin1 and p53 gene in three groups were detected by immunohistochemical SP method, the relationship between the expression of Beclin1 and p53 in the CPA group and the clinicopathological factors, the correlation of the expression of Beclin1 and p53 were analyzed. Results: There were statistical differences in the positive rates of Beclin1 and p53 in the three groups, the positive expression rate of Beclin1 in CPA group were lower than those in PA group and control group, the positive expression rate of p53 in CPA group were lower than those in PA group and control group, and the CPA group was higher than the PA group(P<0.05). The ex-pression of Beclin1 and p53 in group CPA were related to TNM staging and lymph node metastasis, the positive rate of Beclin1 in TNM stage for III-IV patients was lower than that in I-II stage, the positive expression rate of p53 was higher than that in I-II stage, the positive rate of Beclin1 in patients with lymph node metastasis was lower than that of patients without lymph node metastasis, the positive expression rate of p53 was higher than that of the patients without lymph node metastasis, the differences were statistically significant(P<0.05). The expression of Beclin1 and p53 in group CPA were not related to age, sex, tumor diameter and invasiveness(P>0.05).Spearman correlation analysis showed that the expression of Beclin1 and p53 in CPA patients were negatively correlated(r=-0.839, P=0.000). Conclusion: The expression of Beclin1 is low abnormal and p53 is high abnormal in PA and CPA, the expression of Beclin1 and p53 in patients with CPA are related to TNM staging and lymph node metastasis, and the expression of the two is negatively correlated.
- Subjects
P53 antioncogene; CANCER invasiveness; LYMPH nodes; STATISTICAL correlation; ADENOMATOUS polyps
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 19, p3725
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.19.028