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- Title
香菇多糖注射液联合CHOP化疗治疗弥漫性大B细胞淋巴瘤的疗效及 对Bcl-6、Ki-67、VEGF、β2-MG表达的影响
- Authors
吴必嘉; 龚峻梅; 陈娟娟; 黄斯勇; 高飞
- Abstract
Objective: To study the curative efficacy of lentinan injection combined with CHOP chemotherapy in the treatment of Diffuse large B cell lymphoma and its effects on B-cell lymphoma factor-6(Bcl-6), Ki-67 antigen( Ki-67), vascular endothelial growth factor(VEGF), β2-microglobulin(β2-MG). Methods: 64 cases of patients with Diffuse large B cell lymphoma who were treated from Jan2010 to Dec 2011 in our hospital were selected. According to the treatment, the patients treated with lentinan combined with CHOP chemotherapy were taken as the observation group and the patients treated with CHOP chemotherapy alone were considered as the control group. The short-term curative effect, occurrence of adverse reactions, survival rate, positive expression of Bcl-6, Ki-67, VEGF and β2-MG before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group [84.38%(27/32) vs. 53.13(17/32)](P0.05); the positive rate of Bcl-6 was higher than that of the control group [84.38%(27/32) vs. 62.50%(20/32)](P 0.05), the positive rates of Ki-67, VEGF andβ2-MG were lower than those of the control group [31.25%(10/32) vs. 59.38%(19/32), 28.13%(9/32) vs. 56.25%(18/32), 18.75%(6/32)vs. 40.63%(13/32)](P0.05); the total incidence of adverse reactions was lower than that of the control group [21.88%(7/32) vs. 46.88%(15/32)](P0.05); the survival rate at the fifth year follow-up was higher than that of the control group [59.38%(19/32)vs 34.38%(11/32)](P0.05). Conclusion: Lentinan Injection combined with CHOP chemotherapy can effectively improve the short-term efficacy, survival rate and quality of life with high safety in the treatment of diffuse large B cell lymphoma. It may be related to improve the expression of Bcl-6, Ki-67, VEGF and beta 2-MG in tumor tissue.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 11, p2122
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.11.026