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- Title
Orexin 受体1 对摄食条件反射的调控研究.
- Authors
邢乾乾; 胡沙沙; 郭菲菲; 孙向荣; 徐珞
- Abstract
Objective: To investigate the effects of Orexin Receptor1 on Feeding conditioned reflex. Methods: Forty rats were randomly divided into four groups, NS/NS group, SB/SB group, NS/SB group, SB/NS group (n = 8/group). Rats received eight CS-US pairings, where presentations of the CS were immediately followed with delivery of the US, Thirty minutes prior to each session, rats received an injection of either SB or normal saline. Following acquisition, rats received two extinction sessions, each with eight CS-only presentations. The conditioned stimulus (CS) was a 10 s tone (2 kHz), and the unconditioned stimulus (US) was two food pellets delivered into the food cup. Results: All groups increased food cup responding while significantly decreased latency to approach the food cup during each CS across the session. An increase in responding to the CS was confirmed with a significant CS effect. Pretreatment with SB had lower food cup responding and had overall greater latencies to approach the food cup compared to the NS/NS group(p<0.05). During extinction Experiment, SB/NS displayed more food cup behavior compared to the NS/NS and NS/SB groups (p< 0.05) and the difference approached significance with the SB/SB group, The SB/NS group maintained faster latencies to respond to the food cup compared to other groups, groups given SB prior to Extinction session 2 significantly increased their latency during the last two CSs compared to the first two CSs (p< 0.05). Conclusion: These results demonstrate an important role for orexin signaling during Feeding conditioned reflex conditioning and extinction.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 30, p5840
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.30.009