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- Title
The Influence of Ursolic Acid on Bone Formation and Bone Mineral in Alcohol-induced Osteoporosis Rats.
- Authors
CONG Hong-fei; LIANG Hui; GE Na; WU Yan-yan; WANG Wen-cheng; ZHANG Wen-long
- Abstract
Objective: To study influence of Ursolic Acid(UA) on bone formation and bone mineral in alcohol-induced osteoporosis in rats. Methods: Adult male wistar rats(n=10 for each group) were randomly divided into blank control group, UA control group, model group, UA low-, medium-, high group and were respectively given saline, 150 mg/kg UA, 50% alcohol, 50 mg/kg UA, 100mg/kg UA, 150 mg/kg UA. UA control group was administered an equal volume of saline as the blank control group, and UA low-,medium-, high group were received an equal volume of alcohol as the alcohol model group. The rats were administered for 8 weeks. The content of serum phosphorus(P) was detected by phosphate method. The content of serum calcium(Ca) was detected by chromatometry method. Serum bone gla protein(BGP) and bone morphogenetic protein 2(BMP-2) were detected by ELISA. Results: Compared with the blank control group, the contents of serum Ca, P, BGP and BMP-2 were reduced in the model group(P<0.05). Compared with the model group, the contents of serum Ca, P, BGP and BMP-2 were significantly increased in the medium-, and high-dose group(P<0.05). The result of HE staining revealed that bone trabecular was rules, density and uniform thickness in blank control group, and bone trabecular was irregular, sparse, and fracture in the model group. Compared with the model group, bone trabecular was intact, arranged regularly and continuous in the medium-, and high-dose group. Conclusions: Alcohol plays its role in AOP rats by reducing bone formation and promoting bone mineral loss. UA has antiosteoporotic effects on AOP rats by promoting bone formation and reversing bone mineral loss.
- Subjects
BONE growth; URSOLIC acid; OSTEOPOROSIS; LABORATORY rats; BONE morphogenetic proteins; MINERAL content of bones; BODY composition
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 2, p220
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.02.005