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- Title
脐血干细胞移植治疗缺血性心脏病的临床疗效及安全性分析.
- Authors
李卫东; 王玉兵; 陈 丽; 吕 湛; 罗 勇
- Abstract
Objective: To explore the clinical efficacy and safety of umbilical cord blood stem cell transplantation in the treatment of ischemic heart disease (IHD). Methods: A total of 130 patients with IHD, who were treated in Affiliated Hospital of North Sichuan Medical College from January 2011 to January 2013, were randomly divided into observation group(n=65) and control group(n=65). The control group was treated with routine medicine, while the observation group was treated with umbilical cord blood stemcell transplantation. The LVEDV, RVEDV, LVEF of two groups before and 3 months after treatment were compared,and the clinical effect and the improving status of life quality after the treatment were observed. Results: The excellent effect rate(49.23%) and total effect rate(90.77%) of observation group after treatment were significantly higher than that(30.77%) and (70.77%) of control group, the differences were statistically significant (P<0.05). There were no statistical differences in LVEDV, RVEDV and LVEF between the two groups before treatment, but compared with control group, the LVEDV and RVEDV of observation group markedly decreased, LVEF increased after treatment, the differences were statistically significant (all P<0.05). The body functions, exercise limitation and overall health score of observation group were higher than those of control group after treatment, and the differences were statistically significant (all P<0.05). Conclusion: Umbilical cord blood stem cell transplantation has a good effect and high safety in the treatment of patients with IHD, which can significantly improve the heart function and the quality of life, and is worthy of clinical application.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 24, p4677
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.24.018