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- Title
IL-18: The Forgotten Cytokine in Dengue Immunopathogenesis.
- Authors
Nanda, Josephine Diony; Ho, Tzong-Shiann; Satria, Rahmat Dani; Jhan, Ming-Kai; Wang, Yung-Ting; Lin, Chiou-Feng
- Abstract
Dengue fever is an infection by the dengue virus (DENV) transmitted by vector mosquitoes. It causes many infections in tropical and subtropical countries every year, thus posing a severe disease threat. Cytokine storms, one condition where many proinflammatory cytokines are mass-produced, might lead to cellular dysfunction in tissue/organ failures and often facilitate severe dengue disease in patients. Interleukin- (IL-) 18, similar to IL-1β, is a proinflammatory cytokine produced during inflammation following inflammasome activation. Inflammatory stimuli, including microbial infections, damage signals, and cytokines, all induce the production of IL-18. High serum IL-18 is remarkably correlated with severely ill dengue patients; however, its possible roles have been less explored. Based on the clinical and basic findings, this review discusses the potential immunopathogenic role of IL-18 when it participates in DENV infection and dengue disease progression based on existing findings and related past studies.
- Subjects
DENGUE hemorrhagic fever; CYTOKINES; DENGUE; DENGUE viruses; CYTOKINE release syndrome; VIRUS diseases
- Publication
Journal of Immunology Research, 2021, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2021/8214656