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- Title
Role of type I collagen C telopeptide, bone-specific alkaline phosphatase and osteocalcin in the assessment of bone status in postmenopausal women.
- Authors
Trento, Laura K.; Pietropolli, Adalgisa; Ticconi, Carlo; Gravotta, Enrica; De Martino, Massimo U.; Fabbri, Andrea; Piccione, Emilio
- Abstract
Aim: To investigate the clinical role of the bone turnover markers type I collagen C telopeptide (CTX), osteocalcin (OC) and bone-specific alkaline phosphatase (BAP) in the assessment of bone status in women with postmenopausal osteoporosis. Methods: Serum CTX (s-CTX), OC and BAP were measured in 200 healthy menopausal women at their initial visit and were correlated with spine and femur bone mineral density (BMD), determined on dual-energy X-ray absorptiometry. The relationship between biochemical markers of bone turnover and age, age at menopause, body mass index (BMI) and BMD was analyzed using linear correlation. A receiver operating characteristic (ROC) curve was constructed for each serum marker versus both femur and vertebral BMD. Results: No correlation was found between serum levels of OC and BAP and vertebral or femur BMD. A statistically significant inverse correlation was found between s-CTX and BMD at spine and femur. S-CTX levels were higher in women with osteoporosis than in women with normal or moderately low (osteopenic) values of BMD. The sensitivity and specificity versus spine BMD were 73.9% and 41.6% for s-CTX, 40.4% and 80.6% for BAP, and 68.3% and 39% for OC, respectively. The sensitivity and specificity versus femur BMD were 76.9% and 40.4% for s-CTX, 23.8% and 88.3% for BAP, and 80.4% and 53.3% for OC, respectively. Conclusions: Determination of s-CTX, BAP and OC is of limited clinical value in the initial evaluation of bone status in menopausal women.
- Subjects
COLLAGEN; ALKALINE phosphatase; OSTEOPOROSIS in women; BONE density; BIOMARKERS; WOMEN'S health
- Publication
Journal of Obstetrics & Gynaecology Research, 2009, Vol 35, Issue 1, p152
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/j.1447-0756.2008.00868.x