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- Title
Abstract of Acta Obstetrica Et Gynaecologica Japonica, Vol. 54, No. 9 The Retrospective Study of Second-line Chemotherapy in Ovarian Cancer.
- Authors
Nishii, Hiroshi; Yasuda, Makoto; Wachi, Toshiki; Kimura, Eizo; Ochiai, Kazuhiko; Ochiai, Kazunori; Tanaka, Tadao
- Abstract
To evaluate the efficacy of Second-line Chemotherapy for ovarian cancer not from short term efficacy but from the survival rate. Eighty-seven patients with epitherial ovarian cancer treated with Second-line chemotherapy from 1993 were examined retrospectively. All the patients were treated with platinum as first line chemotherapy (≥ 3 courses). Paclitaxel was used for Second-line Chemotherapy in 25 patients. The Kaplan-Meier Method and Log-Rank Test were carried out for the cumulative survival rate and analysis. The Median Survival Time of all patients after Second-line Chemotherapy was 23.6 months. Any significant difference in the survival rate was recognized only by the histological diagnosis (p < 0.0001). There was no significant difference in the survival rates whether patients were treated with paclitaxel as second line chemotherapy or not (p = 0.1915). The disease free survival period of the Second Look Laparotomy (SLL) negative group (23.9 months) is longer than that of SLL positive group (6.2 months). The survival rate after Second-line Chemotherapy was influenced only by histological diagnosis. ACTA OBST GYNAEC JPN Vol. 54, No. 9, pp. 1429–1436, 2002
- Subjects
DRUG therapy; OVARIAN diseases; CANCER patients; ABDOMINAL surgery; DRUGS; SYMPTOMS
- Publication
Journal of Obstetrics & Gynaecology Research, 2003, Vol 29, Issue 1, p56
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1046/j.1341-8076.2003.00075.x