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- Title
Persistence of solifenacin therapy in patients with overactive bladder in the clinical setting: a prospective, multicenter, observational study.
- Authors
Kim, T. H.; You, H. W.; Park, J. H.; Lee, J. G.; Choo, M.‐S.; Park, W. H.; Lee, J. Z.; Park, C. H.; Na, Y. G.; Kwon, D. D.; Lee, K.‐S.; Kim, Hawn; Park, Chang Myon; Kim, Hyeong Gon; Yoo, Eun Sang; Seo, Young Jin; Lee, Sun‐Ju; Choi, Seong; Noh, Joon Hwa; Kim, Duk Yoon
- Abstract
<bold>Objectives: </bold>The aim of this study was to evaluate the persistence with solifenacin therapy over a 12-month period in patients with overactive bladder (OAB).<bold>Methods: </bold>This is a 52-week long, multicenter, prospective, observational study. The subjects were individuals ≥ 18 years old with OAB symptoms for ≥ 3 months, characterised by a total OAB Symptom Score (OABSS) of ≥ 3 and OABSS urgency item score of ≥ 2. Patients were prescribed 5 mg or 10 mg of solifenacin once daily for OAB symptoms. Drug persistence, reasons for discontinuation and factors related to the persistence were evaluated.<bold>Results: </bold>A total of 1018 patients (329 men, 689 women) with a mean age of 59 years were included. The 52-week drug persistence rate was 22.1%. The drug persistence rates at 12, 24 and 36 weeks were 72.4%, 45.8% and 31.1% respectively. The three most common reasons for discontinuing therapy included symptom improvement in 30.4%, lack of efficacy in 13.4%, and a switch to another antimuscarinic agent in 10.8%. Older patients (odds ratio = 1.02, 95% CI: 1.01-1.04), and female patients (odds ratio = 1.94, 95% CI: 1.37-2.75) were more likely to continue the medication over the 12-month period than were younger, male patients. The number of nocturia episodes was negatively correlated with drug persistence (odds ratio = 0.83, 95% CI: 0.71-0.97).<bold>Conclusions: </bold>There was low persistence (22%) to solifenacin therapy for OAB symptoms over a 12-month period. Older patients, female patients and those with fewer episodes of nocturia were more persistent to therapy than were others.
- Subjects
COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; QUESTIONNAIRES; RESEARCH; URINARY organ diseases; URODYNAMICS; EVALUATION research; TREATMENT effectiveness; OVERACTIVE bladder
- Publication
International Journal of Clinical Practice, 2016, Vol 70, Issue 4, p351
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.12783