We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of Berberis aristata Extract on Inflammatory Mediators in Acetic Acid Induced Colitis in Mice.
- Authors
Anjali, Ganjare; Nishikant, Raut
- Abstract
Berberis aristata is spinous herb native to Northen Himalya. It is commonly known as Daru haldi and belonging to family Berberidaceae. Traditionally and in Ayurveda, it is used for the ailments related to antibacterial and anti-inflammatory activities. It is used as an intestinal antiseptic, bitter stomachic and also exhibits anti neoplastic properties. The aim of present study was to investigate the effects of alcoholic extract of B. aristata on inflammatory mediators (SOD, MDA, MPO, GSH) and to estimate disease activity index (DAI) in colitis in mice with taking into account the weight loss, stool consistency, and occult/gross bleeding. Colitis in mice was induced by colonic administration of 150 pi (5%) acetic acid once, intra rectally on 8th day. B. aristata extract was administered orally (200, 500, 1000 mg/kg; suspending in distilled water) for lldays. Colon length, spleen weights, ulcer area and ulcer index were measured. Histological changes were observed by H & E staining. The results showed that BA extract (500 mg/kg) could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD, reduce the contents of MDA and the level of myeloperoxidase in experimental colitis in a dose-dependent manner compared with the control group. The probable mechanisms of BA may be the modulation of inflammatory mediators and anti oxidant activity.
- Subjects
BERBERIDACEAE; THERAPEUTIC use of plant extracts; ACETIC acid; COLITIS treatment; LABORATORY mice
- Publication
Journal of Ravishankar University, Part-B Science, 2016, Vol 29, p106
- ISSN
0970-5910
- Publication type
Article