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- Title
Non-anaemic iron deficiency impairs response to pulmonary rehabilitation in COPD.
- Authors
Barberan‐Garcia, Anael; Rodríguez, Diego Agustín; Blanco, Isabel; Gea, Joaquim; Torralba, Yolanda; Arbillaga‐Etxarri, Ane; Barberà, Joan Albert; Vilaró, Jordi; Roca, Josep; Orozco‐Levi, Mauricio
- Abstract
Background and objective Non-anaemic iron deficiency ( NAID) might alter the oxygen pathway in health and disease. The current study aims at assessing the impact of NAID on aerobic capacity in patients with chronic obstructive pulmonary disease ( COPD). Methods A prospective sample of 70 non-anaemic COPD patients candidate to participate in an 8-week pulmonary rehabilitation ( PR) programme was studied. Incremental cycling exercise to peak oxygen uptake ( V'O2peak) and constant work-rate exercise at 80% V'O2peak to exhaustion were assessed pre- and post- PR. Training-induced increase of endurance time ( ET) ≥33%, which represented the minimal clinically important difference, classified patients as responders to exercise training. Results The prevalence of NAID was 48% ( n = 34) showing no relationship with the Global Initiative for Chronic Obstructive Lung Disease stages ( P = 0.209). Patients with NAID showed lower pre-training ET ( P = 0.033) and V'O2peak ( P = 0.007) than normal iron status ( NIS) patients after adjustment for potential covariates. Significant training-induced physiological changes were seen in the NIS group (Δ V'O2peak 68(132) mL/min; P = 0.009), but not in the NAID group (Δ V'O2peak 26 (126) mL/min; P = 0.269). The NAID group showed lower percentage of responders to training (56%) than the NIS group (78%) ( P = 0.041). Conclusions COPD patients with NAID showed lower pre-training aerobic capacity and reduced training-induced response than NIS patients after adjusting for potential confounding variables.
- Subjects
IRON deficiency diseases; IRON deficiency anemia; OBSTRUCTIVE lung diseases; AEROBIC capacity; CARDIOPULMONARY fitness
- Publication
Respirology, 2015, Vol 20, Issue 7, p1089
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12591