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- Title
Combination of angiotensin-(1-7) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy.
- Authors
Hao, Panpan; Yang, Jianmin; Liu, Yanping; Zhang, Mingxiang; Zhang, Kai; Gao, Fei; Chen, Yuguo; Zhang, Cheng; Zhang, Yun
- Abstract
We recently found that overexpression of angiotensin (Ang)-converting enzyme 2, which metabolizes Ang-II to Ang-(1-7) and Ang-I to Ang-(1-9), may improve left ventricular remodeling in diabetic cardiomyopathy. Here we aimed to test whether chronic infusion of Ang-(1-7) can dose-dependently ameliorate left ventricular remodeling and function in a rat model of diabetic cardiomyopathy and whether the combination of Ang-(1-7) and Ang-converting enzyme inhibition may be superior to single therapy. Our results showed that Ang-(1-7) treatment dose-dependently ameliorated left ventricular remodeling and dysfunction in diabetic rats by attenuating myocardial fibrosis, myocardial hypertrophy and myocyte apoptosis via both the Mas receptor and angiotensin II type 2 receptor. Furthermore, combining Ang-(1-7) with perindopril provided additional cardioprotection relative to single therapy. Ang-(1-7) administration provides a novel and promising approach for treatment of diabetic cardiomyopathy.
- Subjects
DIABETIC cardiomyopathy; ANGIOTENSINS; CARDIOMYOPATHIES; OLIGOPEPTIDES; APOPTOSIS
- Publication
Scientific Reports, 2015, p8794
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep08794