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- Title
Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis.
- Authors
Jiang, Benchun; Zhu, Ke; Shao, Hua; Bao, Chenhui; Ou, Jinlei; Sun, Wei
- Abstract
E-Cadherin (CDH1) plays a key role in cell adhesion, which is vital to the normal development and maintenance of cells. Down regulation of CDH1, may lead to dysfunction of the cell-cell adhesion system, resulting in increased susceptibility to tumor development and subsequent tumor cell invasion and metastasis. The CDH1 C-160A polymorphism could decrease its transcription efficiency and may increase susceptibility to cancer development, but its relevance to gastric cancer is generally disputed. Consequently, we performed a meta-analysis of published case-control studies, including 4218 gastric cancer cases and 5461 controls. Overall, no significant association was observed between the CDH1 C-160A polymorphism and risk of gastric cancer in all genetic models. In the stratified analysis by total sample size, a significant association was observed in the small sample size subgroup (total sample size < 300), but the results should be interpreted with caution. In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer. Large-scale and well-designed studies are needed to confirm our findings.
- Subjects
POLYMORPHISM (Crystallography); DISEASE susceptibility; STOMACH cancer; META-analysis; CELL adhesion; TRANSCRIPTION factors
- Publication
Scientific Reports, 2015, p7891
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep07891