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- Title
Imparting biomolecules to a metal-organic framework material by controlled DNA tetrahedron encapsulation.
- Authors
Yongmei Jia; Benmei Wei; Ruixue Duan; Ying Zhang; Boya Wang; Abdul Hakeem; Nannan Liu; Xiaowen Ou; Shaofang Xu; Zhifei Chen; Xiaoding Lou; Fan Xia
- Abstract
Recently, the incorporation of biomolecules in Metal-organic frameworks (MOFs) attracts many attentions because of controlling the functions, properties and stability of trapped molecules. Although there are few reports on protein/MOFs composites and their applications, none of DNA/MOFs composite is reported, as far as we know. Here, we report a new composite material which is self-assembled from 3D DNA (guest) and pre-synthesized MOFs (host) by electrostatic interactions and hydrophilic interactions in a well-dispersed fashion. Its biophysical characterization is well analyzed by fluorescence spectroscopy, quartz crystal microbalance (QCM) and transmission electron microscopy (TEM). This new composite material keeps 3D DNA nanostructure more stable than only 3D DNA nanostructure in DI water at room temperature, and stores amounts of genetic information. It will make DNA as a guest for MOFs and MOFs become a new platform for the development of DNA nanotechnology.
- Subjects
RECOMBINANT molecules; BIOMOLECULES spectra; ORGANIC synthesis; ORGANOMETALLIC compounds; ENCAPSULATION (Catalysis); QUARTZ crystal microbalances
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep05929