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- Title
Microbial Aspartic Protease: Bio -synthesis, Characteristics, and Emerging Applications: A review.
- Authors
Hasnawi, Sadeq Fenjan; Abd Al-Manhel, Alaa Jabbar; AL-Younis, Zena Kadhim; Altemimi, Ammar B.; Abedelmaksoud, Tarek Gamal; Hesarinejad, Mohammad Ali
- Abstract
Aspartic proteases play a vital role in diverse biological processes, with microbial variants garnering considerable attention for their commercial potential across various industries. This comprehensive review delves into the intricate aspects of microbial aspartic proteases, encompassing their biosynthesis, genetic regulation, secretion mechanisms, post - translational modifications, characteristics, and emerging applications. The biosynthesis of these proteases involves the translation of corresponding genes into precursor proteins, which undergo a series of processing steps culminating in the formation of mature enzymes. The efficiency of aspartic protease production and commercialization relies heavily on understanding the mechanisms governing their secretion. Notably, post -translational modifications, such as glycosylation and phosphorylation, play a significant role in influencing the activity and stability of these enzymes. The review further explores the substrate specificity and catalytic properties of microbial aspartic proteases, along with their potential applications in the food industry, pharmaceuticals, and biotechnology sectors. In the food industry, these proteases find utility in enhancing flavor, texture, and nutritional value. In the pharmaceutical realm, they contribute to drug discovery and development. Additionally, in biotechnology, microbial aspartic proteases exhibit versatility in applications such as protein engineering, peptide synthesis, and bioremediation. This comprehensive examination provides valuable insights into the multifaceted nature of these enzymes, shedding light on their biosynthesis, genetic regulation, secretion mechanisms, post -translational modifications, characteristics, and promising commercial applications.
- Subjects
ENZYME stability; PROTEIN precursors; GENETIC regulation; MICROBIAL enzymes; DRUG discovery; PEPTIDE synthesis
- Publication
Journal of Food Science & Technology (2008-8787), 2024, Vol 21, Issue 150, p76
- ISSN
2008-8787
- Publication type
Article
- DOI
10.22034/FSCT.21.150.76