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- Title
Epigenetic Memories in Hematopoietic Stem and Progenitor Cells.
- Authors
Aoyama, Kazumasa; Itokawa, Naoki; Oshima, Motohiko; Iwama, Atsushi
- Abstract
The recent development of next-generation sequencing (NGS) technologies has contributed to research into various biological processes. These novel NGS technologies have revealed the involvement of epigenetic memories in trained immunity, which are responses to transient stimulation and result in better responses to secondary challenges. Not only innate system cells, such as macrophages, monocytes, and natural killer cells, but also bone marrow hematopoietic stem cells (HSCs) have been found to gain memories upon transient stimulation, leading to the enhancement of responses to secondary challenges. Various stimuli, including microbial infection, can induce the epigenetic reprogramming of innate immune cells and HSCs, which can result in an augmented response to secondary stimulation. In this review, we introduce novel NGS technologies and their application to unraveling epigenetic memories that are key in trained immunity and summarize the recent findings in trained immunity. We also discuss our most recent finding regarding epigenetic memory in aged HSCs, which may be associated with the exposure of HSCs to aging-related stresses.
- Subjects
HEMATOPOIETIC stem cells; KILLER cells; EPIGENETICS; MONOCYTES; BONE marrow; NUCLEOTIDE sequencing
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 14, pN.PAG
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11142187